infiTOF

2022.01.05

infiTOFとは

JST大学発ベンチャー創出推進事業で，「MULTUM-S」のイオン光学系を基に実用化を目指して開発した「MULTUM-S II」の技術移転により，大阪大学発ベンチャー「MSI.TOKYO株式会社」を立ち上げて，製品化した装置です．真空排気系や制御系込みでサイズは50 cm × 60 cm × 30 cm以下，重量は35kg以下でありながら，質量分解能は３万以上が達成できる装置です．

小型で高分解能が得られるという特徴を活かし，工場の生産ラインに装置を設置してリアルタイムでガスのモニタリングをするといった用途に使われています．また，大学の研究では，屋外に持ち出してオンサイトでの質量分析も行っています．

現在は電子イオン化（EI）イオン源を有した装置になっていますが，FABやMALDIや大気圧イオン源を有する装置の開発も行っています．

infiTOF関連論文など

  1. 揮発性有機化合物の直接その場分析に向けたプロトン移動反応イオン化 – マルチターン飛行時間型質量分析装置の開発: 河井洋輔・河居伸哉・古谷浩志・石原盛男・渡辺励起・中山邦彦・神納育則・畠山典久・豊田岐聡, J. Mass Spectrom. Soc. Jpn., 69(2021), 68-74.
  2. A method for expanding mass range on a multi-turn time-of-flight mass spectrometer by a lap superimposed spectrum: Toshinobu Hondo, Michisato Toyoda, Mass Spectrometry (Tokyo), 10 (2021), A0098.
  3. Gas chromatography/miniaturized time-of-flight mass spectrometry technique for high-throughput quantitative on-site field analysis: Toshinobu Hondo, Noriko Nakayama, Michisato Toyoda, Int. J. Mass Spectrom., 463 (2021), 116555.
  4. Evaluation of microchannel plate gain drops caused by high ion fluxes in time-of-flight mass spectrometry: A novel evaluation method using a multi-turn time-of-flight mass spectrometer: Hiroshi Kobayashi, Toshinobu Hondo, Michisato Toyoda, J. Mass Spectrom., 56 (2021), e4706.
  5. Mass spectrometric multiple soil-gas flux measurement system with a portable high-resolution mass spectrometer (MULTUM) coupled to an automatic chamber for continuous field observations: Noriko Nakayama, Yo Toma, Yusuke Iwai, Hiroshi Furutani, Toshinobu Hondo, Ryusuke Hatano, and Michisato Toyoda, Atmos. Meas. Tech.,13 (2020), 6657–6673.
  6. Development of novel ion detector that combines a microchannel plate with an avalanche diode: Hiroshi Kobayashi, Toshinobu Hondo, Naruaki Imaoka, Motohiro Suyama, Michisato Toyoda, Nuclear Inst. and Methods in Physics Research, A, 971 (2020), 164110.
  7. Selective extraction of a monoisotopic ion while keeping the other ions in flight on a multi-turn time-of-flight mass spectrometer: Toshinobu Hondo, Hiroshi Kobayashi, Michisato Toyoda, Mass Spectrometry (Tokyo), 9 (2020), A0088.
  8. A new approach for accurate mass assignment on a multi-turn time-of-flight mass spectrometer: Toshinobu Hondo, Kirk R Jensen, Jun Aoki and Michisato Toyoda, Eur. J. Mass Spectrom., 23 (2017), 385-392.
  9. Instrumentation and Method Development for On-site Analysis of Helium Isotopes: Kirk R. Jensen, Toshinobu Hondo, Hirochika Sumino, and Michisato Toyoda, Anal. Chem., 89 (2017), 7535–7540.
  10. Real time monitoring of gases emitted from soils using the Multi-turn Time-of-Flight Mass Spectrometer “MULTUM-S II”: Takahiro Anan, Shuichi Shimma, Yo Toma, Yasuyuki Hashidoko, Ryusuke Hatano, Michisato Toyoda,Environmental Science: Processes & Impacts,16 (2014), 2752 – 2757.
  11. Development of a miniaturized multi-turn TOF mass spectrometer with a pulsed FAB ion source: Hirofumi Nagao, Shinichi Miki and Michisato Toyoda, Eur. J. Mass Spectrom., 20 (2014), 215–220.
  12. Ultra-High Mass Resolution Miniaturized Time-of-Flight Mass Spectrometer “infiTOF” for Rapid Analysis of Polychlorinated Biphenyls: Shuichi Shimma, Shinichi Miki, Robert B. Cody, Michisato Toyoda, Comprehensive Analytical Chemistry, 61 (2013), 303-323.
  13. [総説]マルチターン飛行時間型質量分析計: 豊田岐聡, 新間秀一, 青木順, 石原 盛男, J. Mass Spectrom. Soc. Jpn., 60 (6) (2012), 87-102
  14. Miniaturized Mass Spectrometer in Analysis of Greenhouse Gases: The Performance and Possibilities: Shuichi Shimma and Michisato Toyoda, Greenhouse Gases – Emission, Measurement and Management, Dr Guoxiang Liu (Ed.), ISBN: 978-953-51-0323-3, InTech, Chapter 11 (2012), 235-254.
  15. Polychlorinated biphenyls (PCBs) analysis using a miniaturized high-resolution time-of-flight mass spectrometer “MULTUM-S II”: huichi Shimma, Shinichi Miki and Michisato Toyoda, J. Environ. Monit., 14 (2012), 1664-1670.
  16. Miniaturized high-resolution time-of-flight mass spectrometer “MULTUM-S II” with an infinite flight path: Shuich Shimma, Hirofumi Nagao, Jun Aoki, Keiji Takahashi, Shinichi Miki and Michisato Toyoda, Anal. Chem., 82 (2010), 8456-8463.
  17. Development of Multi-turn Time-of-Flight Mass Spectrometers and Their Applications: Michisato Toyoda, Eur. J. Mass Spectrom., 16 (2010), 397-406.
  18. Multi-turn Time-of-Flight Mass Spectrometers with Electrostatic Sectors : Michisato Toyoda, Daisuke Okumura, Morio Ishihara and Itsuo Katakuse, J. Mass Spectrom., 38 (2003), 1125-1142.
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